Pathirana is a common Sinhalese surname. People with that name include:
Buddhika Pathirana, Sri Lankan politician Jaya Pathirana, Sri Lankan politician and judge Matheesha Pathirana, Sri Lankan cricketer Nandasena Pathirana, Sri Lankan cricket umpire Ramesh Pathirana, Sri Lankan politician Richard Pathirana, Sri Lankan politician R. P. A. Ranaweera Pathirana, Sri Lankan politician Sachith Pathirana, Sri Lankan cricketer Shehan Pathirana, Sri Lankan rugby player Assassination of Daya Pathirana
See also Barred danio (Devario pathirana), a species of fish