Serna is a surname. Notable people with the name include:
Alexis Serna (born 1985), American player of gridiron football Andrea Serna (born 1977), Colombian model, TV presenter, reporter, and producer Assumpta Serna (born 1957), Spanish actress Diego Serna (born 1973), Colombian footballer Dillon Serna (born 1994), American soccer player Elkin Serna, Colombian Paralympic marathon runner Enrique Serna, (born 1959), Mexican author and screenwriter Isaac Serna (born 1955), Peruvian politician Jared Serna (born 2002), Mexican baseball player Joe Serna Jr. (1939–1999), American civil rights activist and mayor of Sacramento Jorge Horacio Serna (born 1979), Colombian footballer Léa Serna (born 1999), French figure skater Lily Serna (born 1986), Australian mathematician and television presenter Magüi Serna (born 1979), Spanish tennis player Marcelino Serna (1896–1992), Mexican immigrant and United States Army soldier Marco Antonio Serna Díaz (1936–1991), Colombian herpetologist, ornithologist, and naturalist Maria Serna (born 1959), Spanish mathematician and computer scientist Mauricio Serna (born 1968), Colombian footballer Patricio M. Serna, New Mexican Supreme Court Justice Paul Serna (born 1958), American baseball player Pepe Serna (born 1944), American film and television actor and artist Ralph Serna (born 1957), American long-distance runner Ricardo Serna (born 1964), Spanish footballer Snooky Serna (born 1966), Filipina film and television actress Sara Serna (born 1987), Spanish footballer Viviana Serna (born 1990), Colombian actress and presenter
See also Sernas La Serna (disambiguation) de la Serna