de la Serna is a surname. Notable people with the name include:
Ernesto "Che" Guevara de la Serna (1928-1967), Argentine Marxist revolutionary, guerrilla leader and politician Jacobo de la Serna (born 1965), American ceramic artist, Spanish Colonial scholar, and painter Jorge Juan Crespo de la Serna (1887–1978), Mexican artist, art critic and art historian José de la Serna e Hinojosa (1770–1832), Spanish general and Viceroy of Peru Juan Pérez de la Serna (1570–1631), seventh Archbishop of Mexico Pedro Gómez de la Serna (1806–1871), Spanish jurist and politician Ramón Gómez de la Serna (1888–1963), Spanish writer Rodrigo de la Serna (born 1976), Argentine actor
See also Serna Sernas La Serna (disambiguation) De la Serna family