Escalera is a Spanish surname. Notable people with the surname include:
Alfredo Escalera (born 1952), Puerto Rican boxer Alfredo L. Escalera (born 1995), Puerto Rican baseball player Carlos Escalera (born 1979), Puerto Rican baseball player Katia Escalera, Bolivian singer Nino Escalera (1929–2021), Puerto Rican baseball player Rodolfo Escalera (1929–2000), Mexican-American artist Irene Cara Escalera (1959-2022), American singer, songwriter, and actress
See also Carlos Escaleras (1958–1997), Honduran politician and activist