De Filippo and its anglicised variant DeFilippo are surnames of Italian origin. People with those names include:
Eduardo De Filippo (1900–1984), Italian actor, playwright, screenwriter, author and poet Gene DeFilippo (born ), American sports executive and former college athletics administrator Gennaro De Filippo (1816–1887), Italian politician Jessica De Filippo (born 2001), Canadian soccer player John DeFilippo (born 1978), American football player and coach Lou DeFilippo (1916–2000), American football player Luca De Filippo (1948–2015), Italian actor and director of theatre Luigi De Filippo (1930–2018), Italian actor, stage director and playwright Marco De Filippo (born 1990), Italian ice hockey player Patrick DeFilippo (1939–2013), American mobster Peppino De Filippo (1903–1980), Italian actor Rebecca De Filippo (born 1994), Welsh rugby union player Titina De Filippo (1898–1963), Italian actress and playwright Vincent J. DeFilippo, master doll sculptor with Ideal Toy Company Vito De Filippo (born 1963), Italian politician
See also De Filippi, a surname