Mustoe is a surname. Notable people with the surname include:
Anne Mustoe (1933–2009), English cyclist and writer Jordan Mustoe (born 1991), English footballer Lyndon Mustoe (born 1969), Welsh rugby union player Neil Mustoe (born 1976), English footballer Richard Mustoe (born 1981), Welsh rugby union player Robbie Mustoe (born 1968), English footballer, manager and commentator William Robert Mustoe (1878–1942), English landscape gardener