Siege of Negroponte can refer to one of two sieges of the town of Chalkis in Greece (medieval Negroponte):
Siege of Negroponte (1257–58), 13-month siege of Negroponte by the Venetians and their allies Siege of Negroponte (1351) by the Genoese Siege of Negroponte (1470) by the Ottoman Turks Siege of Negroponte (1688) by the Venetians
See also Siege of Euripos