Mattox is a surname. Notable people with the surname include:
Bain Mattox, American musician Bernadette Mattox, American basketball coach Cloy Mattox (1902–1985), American baseball player Jim Mattox (1943–2008), American lawyer and politician Jim Mattox (baseball) (1896–1973), American baseball player Jon Mattox, American composer Kenneth Mattox (born c. 1938), American surgeon Martha Mattox (1879–1933), American actress Marv Mattox, American football player Matt Mattox (1922–2013), American jazz and ballet dancer Ray Mattox (1927–2005), American politician
See also Mattox Bastion, mountain of Antarctica Mattox Creek, river in Virginia, United States