Massaquoi is a surname. Notable people with the surname include:
Alloysious Massaquoi, Liberian-Scottish musician in the band Young Fathers Erika Massaquoi, American fashion designer and curator Fatima Massaquoi (1912-1978), Liberian writer Francois Massaquoi (died 2001), Liberian warlord and politician Hans Massaquoi (1926–2013), American journalist and writer Jonathan Massaquoi (born 1988), American football player Mohamed Massaquoi (born 1986), American football player Momulu Massaquoi (1869–1938), Liberian diplomat Nathaniel Varney Massaquoi (1905–1962), Liberian doctor Roland Massaquoi, Liberian politician Tim Massaquoi (born 1982), American football player