Afifa is either a surname or a given name.
Notable people with the surname Abdulla Afifa (born 1991), Qatari footballer Mohamed Saeed Afifa (born 1962), Qatari footballer
Notable people with the given name Afifa Al Shartouni (1886–1906), Lebanese author Afifa Iskandar (1921–2012), Iraqi singer Afifa Karam (1883–1924), Lebanese-American journalist, novelist, and translator