Afkhami is a surname. Notable people with the surname include:

Behrooz Afkhami (born 1956), Iranian film director and screenwriter Gholam Reza Afkhami (1936–2024), Iranian historian Mahnaz Afkhami (born 1941), Iranian academic, activist, and writer Shahruz Afkhami (born 1962), Iranian politician

See also Afkham