Khamis is both a surname and a given name. Notable people with the name include:
Surname: Abubaker Kaki Khamis (born 1989), Sudanese Olympic middle-distance runner Ahmed Khamis (born 1985), Emirati football player Buku Khamis (born 2000), South Sudanese-Australian rules footballer Imad Khamis (born 1961), Syrian politician Johnny Khamis, American politician Leena Khamis (born 1986), Australian football player Mwajuma Hassan Khamis, Tanzanian politician Salem Khamis (born 1980), United Arab Emirates football player Sham Khamis (born 1995), Australian football player Vuai Abdallah Khamis (born 1960), Tanzanian politician Younis Khamis (born 1982), United Arab Emirates basketball player
Given name: Khamis Abakar (1964–2023), Sudanese politician, activist, and former army commander Khamis Gaddafi (1983–2011), Libyan military commander Khamis Bar Qardahe, 13th century Church of the East author