Scalise is a surname. Notable people with the surname include:
Frank Scalice (1893–1957), American mobster George Scalise, American labor leader John Scalise (1900–1929), American mobster Joseph Scalise (born 1937), American mobster Lawrence F. Scalise (1933–2015), Iowa Attorney General Manuel Scalise (born 1981), Italian footballer Steve Scalise (born 1965), United States Congressional Representative from Louisiana