S-methyl-5'-thioadenosine deaminase (, MTA deaminase, 5-methylthioadenosine deaminase) is an enzyme with systematic name S-methyl-5'-thioadenosine amidohydrolase. This enzyme catalyses the following hydrolysis reaction, giving ammonia as a byproduct:
The enzyme from Thermotoga maritima also functions as an S-adenosylhomocysteine deaminase. In Pseudomonas aeruginosa this is the first step in the catabolism of 5′-methylthioadenosine. The product is acted on by S-methyl-5'-thioinosine phosphorylase to give S-methyl-5-thio-α-D-ribose 1-phosphate and hypoxanthine.
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