Gascoyne is a surname. Notable people with the surname include:
Chris Gascoyne (b. 1968), English actor known for his role as Peter Barlow in the soap opera Coronation Street Crisp Gascoyne (1700–1761), English businessman who became Lord Mayor of London David Gascoyne (1916–2001), English poet associated with the Surrealist movement Isaac Gascoyne (1763–1841), British Army officer and Tory politician James Gascoyne DFC (1892–1976), English World War I flying lieutenant James Gascoyne-Cecil, 2nd Marquess of Salisbury (1791–1868), English Conservative politician James Gascoyne-Cecil, 4th Marquess of Salisbury (1861–1947), Chancellor of the Duchy of Lancaster Joel Gascoyne (bap. 1650–1704), English chartmaker, mapmaker and surveyor Mike Gascoyne (b. 1963), British Formula One designer and engineer Thomas Gascoyne (1876–1917), English professional cycling champion