de Santi or Desanti is a surname. Notable people with the surname include:
Antonio Álvarez Desanti (born 1958), Costa Rican politician Dominique Desanti (1920–2011), French writer Guido De Santi (1923–1998), Italian cyclist Marco de Santi (born 1983), Brazilian vert skater Jean-Toussaint Desanti (1914–2002), French educator and philosopher
See also DeSantis De Sanctis (disambiguation)