De Filippis or Defilippis is an Italian surname. Notable people with the surname include:
Cristiana De Filippis (born 1992), Italian mathematician Daisy Cocco De Filippis (born 1949), Dominican-American writer and educator Joseph DeFilippis (born 1967), American activist Lodovico De Filippis (1915-?), Italian footballer Luis De Filippis, Italian Canadian film director and screenwriter Maria Teresa de Filippis (1926–2016), Italian racing driver Mauro De Filippis (born 1980), Italian sport shooter Melchiorre De Filippis Delfico (1825–1895), Italian artist, composer, singer, conductor, and writer Nino Defilippis (1932–2010), Italian cyclist Nunzio DeFilippis, American writer Roberto De Filippis (born 1988), Italian footballer