Cyclic-guanylate-specific phosphodiesterase (EC 3.1.4.52, cyclic bis(3′→5')diguanylate phosphodiesterase, c-di-GMP-specific phosphodiesterase, c-di-GMP phosphodiesterase, phosphodiesterase, phosphodiesterase A1, PDEA1, VieA) is an enzyme with systematic name cyclic bis(3′→5′)diguanylate 3-guanylylhydrolase. It catalyses the following reaction:
The enzyme characterised from Acetobacter xylinum hydrolyses the second messenger, cyclic di-GMP, to 5′-phosphoguanylyl(3′→5′)guanosine (pGpG). It contains heme and requires Mg2+ or Mn2+ for activity; it is inhibited by Ca2+ and Zn2+. This reaction regulates how bacteria switch between their free living and biofilm modes of growth.
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