3',5'-cyclic-AMP phosphodiesterase

3′,5′-cyclic-AMP phosphodiesterase (EC 3.1.4.53, cAMP-specific phosphodiesterase, cAMP-specific PDE, PDE1, PDE2A, PDE2B, PDE4, PDE7, PDE8, PDEB1, PDEB2) is an enzyme with systematic name 3′,5′-cyclic-AMP 5′-nucleotidohydrolase. It catalyses the following reaction

The enzyme characterised from Escherichia coli and mammalian cardiac tissue hydrolyses cyclic adenosine monophosphate to adenosine monophosphate. It requires Mg2+ or Mn2+ for activity. It has also been found in Trypanosoma species, Dictyostelium, and Leishmania major.

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