Crain is a surname. Notable people with the surname include:
Rance Crain (born 1938) publisher, Crain Communications, Inc..
Clayton Crain, comic book artist Dunham Jones Crain (1831–1908), New York politician and diplomat Floyd H. Crain (1929–2023), American politician Hartwell Crain (1900–1981), American politician Jeanne Crain (1925–2003), actress Jesse Crain (born 1981), baseball player John L. Crain, president of Southeastern Louisiana University Kurt Crain (1964–2012), American football player Lavi Crain (born 2010), American artistic gymnast Oleta Crain (1913–2007), African-American military officer, federal civil servant Robert Crain (1865–1928), American lawyer and farmer Samantha Crain (born 1986), American musician Thomas C. T. Crain (1860–1942), New York County D.A. William C. Crain (1798–1865), New York politician