2-deoxystreptamine N-acetyl-D-glucosaminyltransferase (, btrM (gene), neoD (gene), kanF (gene)) is an enzyme with systematic name UDP-N-acetyl-alpha-D-glucosamine:2-deoxystreptamine N-acetyl-D-glucosaminyltransferase. It catalyses the following chemical reaction
The enzyme transfers an N-acetylglucosamine sugar unit to one of the hydroxy groups of the aminoglycoside, 2-deoxystreptamine, giving 2'-N-acetylparomamine and uridine diphosphate (UDP). This is an early step in the biosynthesis of clinically important aminoglycoside antibiotics including neomycin and kanamycin.
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