Southworth is a surname. Notable people with the surname include:
Albert Southworth (1811–1894), co-proprietor of Southworth & Hawes studio Azariah Southworth (born 1987), American music producer and broadcaster Benjamin Southworth (1878–1924) American football player, physician and surgeon. Bill Southworth (born 1946), American baseball player. Billy Southworth (1893–1969), American baseball player and manager Billy Southworth Jr. (1917–1945), American baseball player and bomber pilot Bobby Southworth (born 1969), American mixed martial arts fighter Dorothy Fay Southworth (1915–2003), American actress also known as Dorothy Fay E. D. E. N. Southworth (1819–1899), American writer Effie A. Southworth (1860–1947), American botanist and plant pathologist George Clark Southworth (1890–1972), American radio engineer discoverer of waveguides Gilbert de Southworth (b. 1270), architect of Samlesbury Hall Helen Southworth (born 1956), United Kingdom politician John Southworth (martyr) (1592–1654), English Catholic martyr John Southworth (musician) (born 1972), Canadian pop singer-songwriter Lucinda Southworth, wife of Google co-founder Larry Page
Fictional characters: Miss Ellie Ewing Farlow, née Southworth, character in the American television series Dallas