Southwick is a surname. Notable people with the surname include:
Alfred P. Southwick (1826–1898), American inventor Cassandra Burnell Southwick (c.1600–1660), early American settler Clyde Southwick (1886–1961), American baseball player Dan Southwick, American musician Danny Southwick (born 1981), American football player David Southwick (born 1968), Australian politician Elisha Southwick (1809–1875), American tanner George N. Southwick (1863–1912), American politician Lawrence Southwick (c.1600–1660), early American settler Leslie H. Southwick (born 1950), American judge Shawn Southwick, wife of American television and radio host Larry King Solomon Southwick (1773–1839), New York newspaper publisher and politician Teresa Southwick, American writer Thankful Southwick (1792–1867), American Quaker, abolitionist, and women's rights activist Wayne Southwick (born 1923), American orthopedic surgeon