Ent-kaurene oxidase (, Formerly ) is an enzyme with systematic name ent-kaur-16-ene,NADPH:oxygen oxidoreductase (hydroxylating). This enzyme catalyses the following chemical reaction
ent-kaur-16-ene + 3 NADPH + 3 H+ + 3 O2 ent-kaur-16-en-19-oate + 3 NADP+ + 4 H2O (overall reaction) (1a) ent-kaur-16-ene + NADPH + H+ + O2 ent-kaur-16-en-19-ol + NADP+ + H2O (1b) ent-kaur-16-en-19-ol + NADPH + H+ + O2 ent-kaur-16-en-19-al + NADP+ + 2 H2O (1c) ent-kaur-16-en-19-al + NADPH + O2 ent-kaur-16-en-19-oate + NADP+ + H2O
Ent-kaurene oxidase is a cytochrome p450 class enzyme.
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