TRNA-dihydrouridine20 synthase (NAD(P)+) (, Dus2p, tRNA-dihydrouridine synthase 2) is an enzyme with systematic name tRNA-5,6-dihydrouracil20:NAD(P)+ oxidoreductase. This enzyme catalyses the following chemical reaction

5,6-dihydrouracil20 in tRNA + NAD(P)+ uracil20 in tRNA + NAD(P)H + H+

This enzyme specifically modifies uracil20 in tRNA.

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