Polyprenol reductase (, SRD5A3 (gene), DFG10 (gene)) is an enzyme with systematic name . This enzyme catalyses the following chemical reaction

ditrans, polycis-dolichol + NADP+ ditrans, polycis-polyprenol + NADPH + H+

The reaction occurs in the reverse direction.

See also SRD5A3 DFG10

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