Sulfoacetaldehyde dehydrogenase (acylating) (, SauS) is an enzyme with systematic name 2-sulfoacetaldehyde:NADP+ oxidoreductase (CoA-acetylating). This enzyme catalyses the following chemical reaction

2-sulfoacetaldehyde + CoA + NADP+ sulfoacetyl-CoA + NADPH + H+

The enzyme is involved in degradation of sulfoacetate.

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