Van Blerk is a Dutch noble surname. Notable people with the surname include:
Bok van Blerk (born 1978), South African singer-songwriter who sings in Afrikaans Cliff van Blerk (1938–2018), Australian soccer player (1924–1997), Dutch pianist Hendrik van Blerk (1915–2010), South African journalist and writer Irvette van Zyl (born Irvette van Blerk, 1987), South African Olympic long-distance runner Jason van Blerk (born 1968), Australian soccer player