Van Brussel is a surname. Notable people with the surname include:
Hendrik Van Brussel (born 1944), Belgian mechanical engineer Henk van Brussel (1936–2007), Dutch footballer and manager Hermanus van Brussel (1763–1815), Dutch painter and engraver Marianne Van Brussel, Belgian paralympic athlete Paul Theodor van Brussel (1754–1795), Dutch painter
See also Brussel, a surname