Vilakazi is a surname. Notable people with the surname include:
Bavumile Vilakazi (1955–2005), South African politician Benedict Vilakazi (soccer) (born 1982), South African footballer Benedict Wallet Vilakazi (1906–1947), South African poet, novelist and educator Herbert Vilakazi (1943–2016), South African sociologist Nhlanhla Vilakazi (born 1987), South African footballer S'bongiseni Vilakazi, South African politician Sibusiso Vilakazi (born 1989), South African footballer