Shirk is a surname. Notable people with the surname include:
Amos Urban Shirk (c. 1890 – 1956), American businessman Bill Shirk (born 1945), American escape artist Dave Shirk, visual effects supervisor Eugene Shirk (1901–1994), American politician Gary Shirk (born 1950), American football player George H. Shirk (1913–1977), American lawyer and historian James Shirk (1832–1873), American naval officer John Shirk (1917–1993), American football player Marshall Shirk (born 1940), American player of Canadian football Mary Kimberly Shirk (1880–1979), American philanthropist Matthew Shirk (born 1973), American lawyer Susan Shirk (born c. 1945), American academic