Jeffress is an English surname. Notable people with the surname include:
Arthur Jeffress (1905–1961), arts patron Gary Jeffress, American academic Gene Jeffress (born 1948), American politician Jeremy Jeffress (born 1987), American baseball pitcher Neville Jeffress (1920–2007), Australian advertising executive Robert Jeffress (born 1955), American pastor Steven Jeffress (born 1975), Australian golfer