Jefferis may refer to:
Surname Albert W. Jefferis (1868–1942), Nebraska Republican politician Barbara Jefferis (1917–2004), Australian author Barbara Jefferis Award Frank Jefferis (1884–1938), English (soccer) footballer Gregory Jefferis, British neuroscientist Harry Jefferis (1867–1947), Australian architect James Jefferis (1833–1917), English Congregational minister in Australia, grandfather of Barbara Joshua Jefferis (born 1985), Australian artistic gymnast Millis Jefferis (1899–1963), British engineer developed unusual weapons during WWII Plummer E. Jefferis (1851–1925), American politician from Pennsylvania Vaughn Jefferis (born 1961), New Zealand equestrian William W. Jefferis (1820–1906), American mineralogist
Given name Alfred Jefferis Turner (1861–1947), Australian pediatrician and entomologist Norman Jefferis Holter (1914–1983), American biophysicist
Buildings Hassall and Jefferis Cottages, inn in South Wales Thomas Jefferis House, building in Council Bluffs, Iowa
Places Jefferis Ford, body of water in Chester County, Pennsylvania Worth–Jefferis Rural Historic District, place in Chester County, Pennsylvania