Ardoin is a surname. Notable people with the surname include:
Alphonse "Bois Sec" Ardoin (1915–2007), American Cajun accordionist Amédé Ardoin (1898–1942), American Creole musician Chris Ardoin, American zydeco accordionist Danny Ardoin, American baseball player John Ardoin (1935–2001) American music critic Kyle Ardoin, American politician from Louisiana Ronald Ardoin, American jockey