2I or 2-I may refer to:
Kosmos-2I Soviet rocket AceKard 2i, one of the Nintendo DS storage devices Base 2i, or Quater-imaginary base The binary icosahedral group 2I SSH 2I (WA), now U.S. Route 97 in Washington The 2i's Coffee Bar in London Polikarpov 2I-N1, alternate name for the Polikarpov DI-1 fighter Kosmos-2I 63S; see List of Kosmos satellites (1–250) 2I/Borisov, the first known interstellar comet
See also I2 (disambiguation)