Chappuis () is a French-language surname from the Arpitan region of eastern France and Francophone Switzerland with various spellings. Notable people with the surname include:
Robert "Bob" Richard Chappuis (1923–2012), American football player Charyl Chappuis, Swiss-Thai footballer Eduardo Dibós Chappuis (called "Chachi"), Peruvian politician Eliane Cat-Tuong Chappuis (born 1978), model, actress, singer, producer of Swiss descent Friedrich-Wilhelm von Chappuis (1886–1942), General der Infanterie Isabelle Chappuis (born 1971), Swiss politician James Chappuis (1854–1934), French chemist Jason Lamy-Chappuis (born 1986, Missoula, Montana, USA), Franco-American ski jumper and cross-country skier Liliane Chappuis (1955–2007), Swiss politician Marie de Sales Chappuis, aka Marie-Thérèse Chappuis, Roman Catholic abbess Paul Emile Chappuis (1816–1887), French photographer, inventor, and manufacturer Philippe Chappuis (born 1967), Swiss comics creator Eustace Chapuys (c. 1490/92–21 January 1556), Savoyard diplomat
There is also a scientific term named after the French chemist James Chappuis. Chappuis absorption, absorption bands in the ozone layer
See also Musée Chappuis-Fähndrich, Develier, Canton of Jura, Switzerland Chapuis