McCuskey is a surname. Notable people with the surname include:
Chandler McCuskey Brooks (1905–1989), American physiologist Elbert S. McCuskey (1915–1997), American flying ace JB McCuskey (born 1981), West Virginia politician John F. McCuskey (born 1947), West Virginia politician and justice of the Supreme Court of Appeals of West Virginia. Michael P. McCuskey (born 1948), American judge Sidney Wilcox McCuskey (1907–1979), American mathematician and astronomer
See also 2007 McCuskey, a main-belt asteroid