Griffioen is a Dutch surname meaning "griffin". The name is thought to derive from a house with the sign of a griffin or a coat of arms, though in the Middle Ages "Griffoen" was also in use as a given name.Grifioen at the Database of Surnames in The Netherlands. People with the surname include:

Annemieke Kiesel (née Griffioen, born 1979), Dutch football midfielder and coach James D. Griffioen (born 1977), American writer and photographer Jiske Griffioen (born 1985), Dutch wheelchair tennis player Sander Griffioen (born 1941), Dutch philosopher

See also 128177 Griffioen, a main belt asteroid named after Roger Griffioen (born 1934), physicist

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