Griffis or Griffiss is a surname. Notable people with the surname include:
Elliot Griffis, composer William Elliot Griffis, orientalist Rhoda Griffis (born 1965), American actress Townsend Griffiss, aviator
See also 16253 Griffis, asteroid Griffiss International Airport, in Rome, New York Griffis Sculpture Park, in Cattaraugus County, New York