James or Jim Gregory may refer to:
Law and politics James J. H. Gregory (1827–1910), American politician and educator James G. Gregory (1843–1932), American politician and Surgeon General of Connecticut Jim Gregory (politician) (elected 2018), American politician from Pennsylvania
Science and medicine James Gregory (mathematician) (1638–1675), Scottish mathematician and astronomer James Gregory (physician) (1753–1821), Scottish physician James Crawford Gregory (1801–1832), Scottish physician James Gregory (mineralogist) (1832–1899), Scottish mineralogist
Sports Jim Gregory (footballer) (1876–1949), Australian rules footballer Jim Gregory (football chairman) (1928–1998), English football club director and chairman Jim Gregory (ice hockey) (1935–2019), Canadian hockey general manager and league executive Jim Gregory (basketball) (born 1949), American basketball player
Others James Monroe Gregory (1849–1915), American professor of Latin and dean at Howard University James Gregory (actor) (1911–2002), American actor James Gregory (prison officer) (1941–2003), South African prison guard, author of Goodbye Bafana James Gregory (comedian) (1946–2024), American comedian James Gregory (historian), British historian