P59, P-59 or P.59 may refer to:

Aircraft Bell XP-59, a proposed American fighter aircraft Bell P-59 Airacomet, an American jet fighter aircraft Partenavia P.59 Jolly, a British prototype training aircraft

Vessels , a submarine of the Royal Navy , a patrol vessel of the Indian Navy , a submarine of the Polish Navy

Other uses p59, an alias of GRASP55, a protein Papyrus 59, a biblical manuscript P59, a state regional road in Latvia