P78 or P-78 may refer to:

FB P-78, a pistol , a submarine of the Royal Navy , a corvette of the Indian Navy North American XP-78, a variant of the North American P-51 Mustang P78 road (Ukraine) Papyrus 78, a biblical manuscript Solwind, a NASA space probe P78, a state regional road in Latvia HS Karathanasis (P 78), a Roussen-class fast attack craft of the Hellenic Navy RSS Sea Dragon (P78), a missile gunboat of the Republic of Singapore Navy