High Frontier may refer to:
The High Frontier, a 1976 book about space colonization by Gerard K. O'Neill High Frontier, Inc., an American think tank established in the 1980s by former Lieutenant General Daniel O. Graham High Frontier (video game), a 1987 video game by ZX Spectrum games High Frontier (board game), a 2010 board wargame by Sierra Madre High Frontier (simulation game) a space colony simulation game by Joe Strout
The High Frontier (album), 2013 album by American band Lumerians The Moon, a natural satellite of Earth
See also High Frontiers, former name of Mondo 2000, American magazine