Spagnolo is an Italian surname, literally meaning "Spanish" or "from Spain" and may refer to:
Anthony Spagnolo, Australian politician Duilio Spagnolo (circa 1927–2005), Italian boxer Kathleen Mary Spagnolo (1919–2016), American artist Renata Spagnolo (born 1989), Italian swimmer
See also Forte Spagnolo Spagnola Spagnoli Spagnuolo Spagnoletto