Spagnola is an Italian surname, meaning literally "Spanish", from and/or of "Spain" and may refer to:
Music and film "La spagnola", an art song by Vincenzo di Chiara (1860–1937) La Spagnola (film), an Australian film
People Ali Spagnola, American musician and comedian John Spagnola (born 1957), American football player
See also Spagnoli Spagnolo