Delta-like 3 (Drosophila), also known as DLL3, is a protein which in humans is encoded by the DLL3 gene. Two transcript variants encoding distinct isoforms have been identified for this gene.
Function
This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Expression of DLL3 is highest in fetal brain. It plays a key role in somitogenesis within the paraxial mesoderm.
Clinical significance
Mutations in this gene cause the autosomal recessive genetic disorder Jarcho-Levin syndrome.
Experimental drugs targeting DLL3 have also been investigated as possible treatments for certain types of lung and neuroendocrine cancer, Tarlatamab and rovalpituzumab tesirine are two prominent examples.
References
External links GeneReviews/NIH/NCBI/UW entry on Spondylocostal Dysostosis, Autosomal Recessive
Further reading