AP-4 complex subunit beta-1 is a protein that in humans is encoded by the AP4B1 gene.
Function
The heterotetrameric adaptor protein (AP) complexes sort integral membrane proteins at various stages of the endocytic and secretory pathways. AP4 is composed of 2 large chains, beta-4 (AP4B1, this protein) and epsilon-4 (AP4E1), a medium chain, mu-4 (AP4M1), and a small chain, sigma-4 (AP4S1)
Interactions
AP4B1 has been shown to interact with AP4M1.
Clinical relevance
AP4-complex-mediated trafficking plays a crucial role in brain development and functioning.
References
Further reading
External links
PDBe-KB provides an overview of all the structure information available in the PDB for Human AP-4 complex subunit beta-1