Nurse Shirley may refer to:
Shirley Chater (born July 30, 1932), American nurse, educational administrator and government official who served as the 12th commissioner of the Social Security Administration Shirley Congdon (born 1961), British nurse and academic administrator who is the eighth and current vice chancellor of the University of Bradford Shirley Dorismond, Canadian politician and former union leader and nurse Shirley Meacham (1927–2010), American nurse and politician Shirley Roberts, a fictional character in the sitcom Scrubs; see Laverne Roberts Shirley Smoyak, a nurse and academic who has had a significant impact on the field of psychiatric nursing