Choline-phosphate cytidylyltransferase () is an enzyme that catalyzes the chemical reaction
The enzyme characterised from guinea pig liver combines cytidine triphosphate and phosphocholine to give citicoline, with pyrophosphate (PPi) as a byproduct. It is responsible for regulating phosphatidylcholine content in membranes.
In humans, the enzyme protein is encoded by the genes PCYT1A and PCYT1B. These have been extensively studied.
This enzyme is a transferase, specifically one transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is CTP:choline-phosphate cytidylyltransferase. Other names in common use include phosphorylcholine transferase, CDP-choline pyrophosphorylase, CDP-choline synthetase, choline phosphate cytidylyltransferase, CTP-phosphocholine cytidylyltransferase, CTP:phosphorylcholine cytidylyltransferase, cytidine diphosphocholine pyrophosphorylase, phosphocholine cytidylyltransferase, phosphorylcholine cytidylyltransferase, and phosphorylcholine:CTP cytidylyltransferase.
Structural studies As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and .
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