Cytidylate kinase () is an enzyme that catalyzes three related chemical reactions. In the first, cytidine monophosphate (CMP) is converted to cytidine diphosphate when a phosphate group is transferred from the cofactor, adenosine triphosphate (ATP), which is converted to adenosine diphosphate (ADP):
The enzyme can also convert the deoxynucleotide, deoxycytidine monophosphate (dCMP) to the corresponding dCDP and it also acts on uridine monophosphate:
The enzyme has been found in Tetrahymena pyriformis, Escherichia coli, Arabidopsis thaliana, Dictyostelium discoideum, and humans.
Nomenclature This enzyme is a transferase, specifically one transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:CMP phosphotransferase. Other names in common use include: deoxycytidylate kinase, deoxycytidylate kinase, CMP kinase, CTP:CMP phosphotransferase, dCMP kinase, deoxycytidine monophosphokinase, UMP-CMP kinase, ATP:UMP-CMP phosphotransferase, and pyrimidine nucleoside monophosphate kinase.
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